Grants - Florida - Designated Grants - 2014

Calvin Lee, Ph.D.

Funded by Tampa Bay Lightning Foundation

Rhabdomyosarcoma is the most common soft tissue tumor in children.  This cancer seems to be related to muscle cells that have not been able to mature normally.  This project is investigating the manipulation certain proteins called polycomb proteins.  The main goal is to determine if polycomb proteins change the production of other genes that are vital to normal cellular maturation in rhabdomyosarcoma.  the hope is to define polycomb proteins as regulators of muscle development and use this information to produce new and targeted treatments for this disease.