Funded by Hooters of America, LLC., in memory of Kelly Jo Dowd
In humans, an early age of first pregnancy reduces the risk of breast cancer by an incredible 30%. The effects or pregnancy on reducing breast cancer risk is present in multiple mammalian species, and confers a long-lasting cancer protection. However, we know little about the modifications that confers breast cells with a cancer resistant state. The goal of our proposal is to understand pregnancy-induced breast cancer protection and to discovery how to manipulate its effects. Our ultimate goal is to devise preventive strategies to mimic the preventive effects of pregnancy and potentially reduces breast cancer occurrence.