Cancer treatment is being improved by ever more specific drugs. But, there is growing proof that cancers growing in different parts of the body do not react to the same drugs, even if the tumor has the same mutation. For example, a lung tumor may respond when given a drug, but a tumor with the same mutation from another part of the body may not react in the same way. Some lung tumors can look a lot like healthy lung tissue, but some look like a completely different tissue. My lab has developed a mouse model of lung cancer that lets us change the state of the tumor from looking like one from the lungs to the stomach. We have shown that this change can happen in human lung cancer too. We will see if this change affects how lung tumors respond to targeted therapy. We will then use this knowledge to improve lung cancer treatment.