Grants - Translational Grants - Massachusetts - 2018

Leonard Zon, M.D.

Funded in partnership with Adenoid Cystic Carcinoma Research Foundation (ACCRF)

We recently found that retinoic acid treatment reduces the growth of a salivary gland tumor.  The retinoic acid has the ability to shut down the cause of the cancer which is due to the overactivity of a gene called c-myb.  Retinoic Acid has been successfully given to patients with a rare type of leukemia and we plan to use the same doses as the leukemia patients.  We will examine whether the retinoic acid is active in the tumor and whether the growth of the tumor is reduced.  Our studies have the possibility of finding the first treatment for this metastatic tumor.

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