Cancer immunotherapy with checkpoint receptor inhibitors (ICIs) causes autoimmune side effects. These side effects occur in most patients treated with ICIs. These side effects are debilitating and difficult to treat. My goal is to find treatments for ICI side effects. I developed new mouse models where ICIs induce the same autoimmune side effects as in humans. I will use these models to understand why ICIs are toxic. I will also understand how to treat the side effects of ICIs.
Martina Damo, PhD
Location: The University of Chicago Medicine Comprehensive Cancer Center - Chicago
Proposal: Mechanisms of checkpoint receptor inhibitor-dependent immune-related Adverse Events in skin and gut
