Mo Motamedi, Ph.D.
Dr. Mo Motamedi at Massachusetts General Hospital Cancer Center in Boston has been using his 2012 V Scholar Grant to research cancer through a study of yeast cells. The genes that humans share with yeast are the most elemental and vital genes an organism needs for life. Against this simple genetic background, Motamedi looks for the effects of a molecular memory system—called epigenetics—which keeps the inheritance of genes “true” during rounds of cell division in yeast and humans. Motamedi’s research may lead to the development of new drugs and new strategies for reprogramming cancer cells to make them more sensitive to therapy.