The number of melanoma cases in the United States continues to rise. When melanoma spreads to other organs, it is very deadly. Patients with this disease are usually first treated with medicines that help the immune system fight the cancer. This treatment works well for some people, but many can’t take the drugs because they have too many side-effects or simply do not work. For others, the medicines shrink the melanomas at first, but then they grow back. When immune medicines stop working, people with some kinds of melanomas can take other medicines(targeted drugs). However, targeted drugs do not work for a type of melanoma called NRAS mutant, which is very deadly and hard to treat. We found that a medicine used to treat leukemia may help targeted drugs work better for patients with this type of melanoma. In this proposal, we will learn how and why the leukemia medicine helps the targeted drugs work. We also will test our FDA-approved leukemia drug together with two different targeted drugs in mice. If the drugs work together to shrink the melanomas, then, in the future, we will test the treatment in patients by starting a clinical trial. Through this work, our goal is to give these patients more time to spend with their families, and eventually find a cure for this terrible disease.
Funded by the Dick Vitale Pediatric Cancer Research Fund
Neuroblastoma is a childhood cancer that develops from nerves outside of the brain. Half of these cancers spread and cause high rates of death despite treatment. Many researchers study how proteins impact cancer growth and spread. Proteins work differently when sugars are attached to them. Sugars are added to proteins through a process called glycosylation, and the way that sugars are added is different in adult cancers. Few people have studied how glycosylation changes the behavior of childhood cancers. We have applied new technology to studying neuroblastomas and found that a certain sugar, fucose, is decreased in advanced tumors. We will extend our work and look at how sugars change when cancer cells are treated with chemotherapy. We found that decreased levels of fucose increases the ability of certain immune cells to find neuroblastoma cells. We have proposed studies to determine how proteins joined to fucose change how neuroblastomas are recognized by white blood cells. The proposed work will be the first use of this technology to define how cancers cells change their sugar patterns to avoid death when treated with chemotherapy.
Prostate cancer is a type of cancer that affects men, and it’s one of the most common types of cancer in the United States. Castration-resistant prostate cancer is a more advanced stage of the disease, which is harder to treat and can be life-threatening. Our research focuses on a protein called TRIM28, which is found at high levels in castration-resistant prostate cancer. We’ve discovered that TRIM28 promotes the growth of cancer cells by activating a specific oncogene. We believe that blocking TRIM28 could be a new way to treat castration-resistant prostate cancer, especially in patients who have lost an important tumor suppressor gene called RB1. Our goal is to develop new drugs that can block the activity of TRIM28, which could help to stop the growth of cancer cells and overcome cancer drug resistance. By better understanding the role of TRIM28 in castration-resistant prostate cancer, we hope to find new ways to treat this disease and improve the lives of patients.
Funded by Mark and Cindy Pentecost in memory of Will DeGregorio
Ewing sarcoma relies on decades-old chemotherapy options, where aggressive treatments are met with poor disease outcomes. Ewing sarcoma is a devastating disease that affects mostly young adults age 10-16, but children under the age 10 can also develop this deadly illness. Due to the disease’s classification as a rare disease (less than 10,000 cases/year), it has not received the attention of the research community like other more common cancers; therefore, it is in desperate need of intense research and development of new therapeutic options. One of the key observations of Ewing sarcoma made back in the 1930’s is the accumulation of large amount of glycogen. Glycogen is a sugar molecule that our body uses to store energy; only specific organs such as the liver and muscle are capable of producing glycogen. The ability of Ewing sarcoma tumors to store large amount of glycogen has been forgotten until now. This proposal aims to understand the reason behind large glycogen accumulation in Ewing sarcoma and exploit the glycogen deposits as a possible drug target for the treatment of Ewing sarcoma.Dr. Sun has established ongoing collaborations with pediatric physicians to study the basis of glycogen targeting agents for the treatment of Ewing’s sarcoma, and to define early diagnostic biomarkersand evaluation of response to therapy.The long-term goal is to establish treatment options using one or multiple modalities as tailored therapies against Ewing’s sarcoma’s metabolic vulnerability.
2017 V Foundation Wine Celebration Volunteer Grant in honor of Susan Leick and Joe McCrary
Lung cancer is the leading cause of cancer-related deaths worldwide, and is a very complex disease with different cell types that make up each tumor. Immunotherapy is ground-breaking because it is able to cure some patients with late stage tumors. However, the number of patients that have this great response is still low. In this proposal, we will test the combination of a second drug with immunotherapy to increase the likelihood that squamous lung tumors will respond to treatment. To do this, we will use two mouse models of squamous cell carcinoma. These models are ideal for testing immunotherapy because they have intact immune systems and have many features of the human disease. We will test whether the second therapy changes the cell types that make up the tumor, and whether these changes lead to better therapy outcomes. If our results show that the second drug can boost the immunotherapy, we can rapidly transition this work to clinical trials in human lung cancer patients.
