Michael Weber, Ph.D.

The goals of “precision medicine” in cancer are (1) to identify the molecules that drive
the cancer and (2) develop “smart drugs” that block these drivers. These “smart drugs”
should stop the cancer but not be toxic. Many “smart drugs” have been developed, but
the cancer cells adapt and find escape routes. We get many hopeful “responses” to
therapy but disappointingly few “cures.” Our research identifies escape routes that
cancer cells use to evade death, and then uses additional drugs to block the escape
from treatment.

Our approach is already showing success in treating a blood cancer called Mantle Cell
Lymphoma. One of our combinations is causing complete responses in over half the
patients we treat. Unfortunately, many cases show resistance to our drugs, even
though the patients had never previously seen them. We are researching the ways that
cancer cells become resistant to these powerful drug combinations. Our goal is to
achieve deeper responses to therapy and turn the frequent “responses” into genuine

Location: UVA Health System - Virginia
Proposal: Understanding and Overcoming Anti-Apoptotic Multi-Drug Tolerance in Non-Hodgkins Lymphoma
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