Yong Zhang, Ph.D.

V Scholar Plus Award – extended funding for exceptional V Scholars

Cancer cells contain a set of highly active proteins. They can add small groups to a series of target proteins. These uncommon additions are often linked with tumors found in breast, liver, and other tissues. To date, it is still unclear how those aberrant additions cause cancer. To answer this question, it is crucial to know all the interaction targets for the additions in cancer cells. But no method has been made available to resolve this key issueIn this project we are aimed to create an innovative platform to achieve this goalOur research plan will use chemistry and biotechnology to make new tools for target identification. A particular member in this group will be chosen for this work. Because it shows much higher activities in diverse types of cancerThe full range of interacting targets for this protein will be clearly determinedMoreover, the patterns and levels of such interactions in cancer cells can be precisely measured by our creative approach. These findings will unveil the interaction networks of this cancerous protein to guide our further studies. The fundamental knowledge obtained from this work will advance our understanding of cancerImportantly, it will foster the development of new approaches for cancer detection and treatment. 

Location: USC Norris Comprehensive Cancer Center - California
Proposal: Mapping Post-Translational Modification-Dependent Interactome in Cancer Cells
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