Brian Patrick O’Neill, M.D.

Professor of Neurology, Mayo Medical School; Director, Mayo SPORE in Brain Cancer; Principal Co-Leader, Neuro-Oncology Program

Dr. Brian Patrick O’Neill is Principal Co-Leader of the Mayo Clinic Cancer Center Neuro-Oncology Program and is Director and Overall Principal Investigator of the Mayo Specialized Program of Research Excellence (SPORE) in Brain Cancer. Dr. O’Neill holds the academic rank of Professor of Neurology.

He has served on National Institutes of Health (NIH) Special Review Panels and committees since 1999, and he serves as a member of The Cancer Genome Atlas Working Group and the Brain Malignancies Steering Committee. Dr. O’Neill is also a member of the editorial board of The Journal of Neuro-Oncology and Neuro-Oncology.

Dr. O’Neill has been appointed to national committees that deal with scientific review, policy creation and governance and advisory functions. He serves on the Executive Committee of the American Academy of Neurology’s Neuro-oncology Section. He is a founding member of the Scientific Advisory Committee of The Sontag Foundation. He is a Charter Member of the Mayo NIH Clinical and Translational Science Award.

Dr. O’Neill’s specific research focus is primary CNS lymphoma (PCNSL), and he has led NIH-supported clinical trials and epidemiologic studies in this lethal but potentially curable brain tumor. His current research focus is on the genomic differences between PCNSL and systemic non-Hodgkins lymphoma (NHL) and the development of an animal model.


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