The Future of BRCA

The Future of BRCA

The V Foundation has joined forces with the BRCA Foundation to put an end to BRCA related cancers!

BRCA 1 and 2 genes are tumor suppressor genes, and we all have them. When working properly, they control the way cells grow in certain tissues in the body. However, when mutated, they can increase the possibility for certain types of cancer to arise. While BRCA gene mutations were first noted to cause higher rates of breast and ovarian cancer and remain prominently linked to those cancers, research has shown they can trigger a variety of cancers throughout the body, in men and women. Learn more about BRCA from the Basser Center, the first comprehensive center for research, treatment and prevention of BRCA-related cancers.

The BRCA Foundation, spearheaded by Evan and Cindy Goldberg, has committed to join forces with the V Foundation for Cancer Research to fund researchers with new and innovative ideas on how to prevent, treat and cure BRCA related cancers. Goldberg, a V Foundation Board Member since 2014, is the Chairman, President and Director of the BRCA Foundation.  The mission of the BRCA Foundation is to accelerate research and foster collaboration in order to prevent and cure BRCA cancers.

BRCA mutations can affect both men and women and be passed down by either parent. They can increase lifetime risk for cancers including breast, ovarian, pancreatic, prostate and melanoma. In fact, BRCA mutations give an increased risk of lifetime cancer of up to 75% for breast, up to 50% for ovarian and up to 25% for prostate.

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Watch the video below to learn more about BRCA.


Fiona Simpkins, M.D.
Co-PIs: Eric Brown, Ph.D. and Payal Shah, M.D.
University of Pennsylvania
Philadelphia, PA
Novel PARP and ATR inhibitor combination therapies for BRCA-mutant ovarian cancer
Funded by 2017 BRCA Fund-A-Need

In a new clinical trial, Simpkins and her team are testing a combination therapy designed to improve the effectiveness of PARP inhibitors in women with BRCA related ovarian cancer. With V Foundation funding, the team is working to identify ways to predict which patients are likely to benefit most from the new therapy and to further refine the drug combination to create the most effective and well-tolerated treatment possible.

Alan Ashworth, Ph.D.
UCSF Helen Diller Family Comprehensive Cancer Center
San Francisco, California
Towards Making PARP Inhibitors a curative treatment for BRCA-related cancers
Funded in partnership with the Goldberg Family Foundation and in collaboration with the Gray Foundation

Using functional genomic approaches, Ashworth and team are investigating mechanisms of resistance and identifying novel genetic vulnerabilities that can be exploited by PARPi treatment. They are also investigating the immune response to BRCA-mutant tumors and exploring ways to improve the ability of immune cells to recognize and kill these tumors. The ultimate goal of these studies is to improve outcomes for patients with BRCA-mutant tumors and to identify new groups of patients that can benefit from PARPi.

James Ford, M.D.
Stanford University School of Medicine
Stanford, California
Stanford Genetic Studies of BRCA1/BRCA2 Associated Tumors & Blood Samples
Funded in partnership with the Goldberg Family Foundation

Dr. Ford and team  are screening for cancer in high-risk individuals using Liquid Biopsies. As part of their collaboration with V Foundation funded investigator Karlene Cimprich, they have begun to look for “R-loops”, abnormal DNA-RNA hybrids formed in response to DNA damage in BRCA mutant cells, in patient plasma samples.  Early studies suggest that they can detect these potential biomarkers in plasma.


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