Florida Archives - Page 8 of 8

Scott Antonia, M.D., Ph.D., Amer Berg, Ph.D., Dung-Tsa Chen, Ph.D.

Adenocarcinoma is the most common type of lung cancer, and the majority of people diagnosed with this disease will die from metastases. Chemotherapy is the standard way to treat this cancer, and this provides clear benefits including increasing the lifespan of patients. However this benefit is limited and all patients eventually become resistant to standard therapy. Therefore new types of treatment need to be developed. Immunotherapy is a type of treatment designed to get a patient’s own immune system to kill their cancer. Very recently it was demonstrated that an immunotherapy called anti-PD1 has surprisingly good activity in lung cancer. Rapid and prolonged regressions of tumors occur in about one quarter of patients. Now it is important to develop combination therapies with this agent that may help the three quarters of patients who do not respond to anti-PD1. One such approach would be to combine anti-PD1 with a therapeutic cancer vaccine. Vaccines are designed to increase the number of lymphocytes in patients that can recognize and kill cancer cells. Many of these sorts of vaccines have been developed that are very effective in accomplishing this lymphocyte expansion, but none have been very good at killing tumors. One reason for this is that tumor cells can produce a protein called PD-L1 that binds to PD1, another protein on the surface of the lymphocytes activated by the vaccines, which shuts down their ability to kill cancer cells. Anti-PD1 prevents this from happening. We propose to combine anti-PD1 with a cancer vaccine for the first time to treat patients with advanced stage lung adenocarcinoma. We will use a vaccine that activates lymphocytes that recognize a protein called mesothelin which is produced by many lung adenocarcinomas and has been shown previously to expand the number of mesothelin-specific lymphocytes in cancer patients. We expect that combining this vaccine with anti-PD1 will be synergistic, producing improved clinical outcomes. We will also comprehensively analyze the immune systems of the patients and characteristics of their tumors which may be responsible for producing resistance to anti-PD1 and/ or the vaccine. This information can then be used to suggest additional agents that can be added to the anti-PD1/ vaccine combination in the future to further improve the effectiveness of this therapy.

Alan P. Fields, Ph.D.

Funded by The V Foundation Wine Celebration Vintner Grant
In honor of Todd Zapolski and Leslie Rudd

Derek C. Radisky, Ph.D., Lynn Hartmann, M.D.

Anna R. Giuliano, Ph.D., Soner Altiok, M.D., Ph.D., Gerold Bepler, M.D., Ph.D., Douglas Cress, Ph.D., Hui-Yi Lin, Ph.D., Matthew B. Schabath, Ph.D.

Gary W. Reuther, Ph.D.

Michael Zinner, M.D.

Funded by Hooters of America, LLC

Baptist Health South Florida is developing Miami Cancer Institute into a destination cancer center known for its leading clinical care, exceptional patient experience, advanced clinical research and state-of-the-art technology – including the first proton therapy center in South Florida, Latin America and the Caribbean. To accelerate its mission of hope, caring and innovation, Miami Cancer Institute has announced plans to join the Memorial Sloan Kettering Cancer Alliance, a dynamic partnership that will ultimately enable cancer patients to access potential breakthrough therapies right here in South Florida.

Hatem Soliman, M.D.

Funded by Hooters of America, LLC

This project attempts to use advanced analytical software (IBM’s Watson) to provide a comprehensive picture of our metastatic breast cancer patient population over a 5 year period at the Moffitt Cancer Center. The projects aims are to capture this dataset over the course of a year and enter in many different data points about the patients. These data points describe what this population of patients looks like from the perspective of an oncologist determining how many of them are eligible for any given trial that they have open. With this information we can use Watson to generate a detailed report to help us understand what types of patients we see, how those groups have changed over time, and most importantly what trials can we seek out to best match up with the patients we see at our center. The goal is to use data analysis to help us plan what mix of different trials we need to open in the future to best serve our patients’ needs.

Robert Gatenby, M.D.

The Robert Shields Memorial Grant for Esophageal Cancer was funded by two fundraisers organized by Frank Cannata: Rolling Thunder’s 2015 “Ride for Freedom,” and The Cannata Report Awards and Charities Dinner

Unlike treatment of other common diseases, cancer therapy is constantly limited by rapid evolution of resistance in the treated (cancer) cells. Unfortunately, the amazing capacity of tumor cells to evolve resistance strategies limits virtually every treatment so that metastatic cancers generally remain fatal.

We propose that, while the ability to evolve confers a great advantage on cancer cells, it also imposes a subtle opportunity for treatment. This is because evolving populations can only adapt to current conditions – they can never anticipate future environments. Importantly we can. In this project we employ a sequence of treatments. The first therapy both actively kills cancer cells and guides the evolution of cancer cells so that development of resistance, although inevitable, uses a cellular strategy that we can attack with the second line therapy. We term this “double bind” cancer treatment strategy. An excellent illustration of this approach is pest management through “predator facilitation.” For example, in the event of a rodent infestation, a farmer may introduce an owl. However, rodents typically adapt to the owl predation by shifting their activity to the safety of shrubs. While this would seem to be discouraging result (similar to evolution of resistance to therapy in cancer), the “resistance” strategy can, in fact, be exploited by the farmer by introducing snakes. This is a double bind because the owls facilitate the hunting success of snakes and vice-versa. In this project we construct a similar evolutionary dynamics for treating esophageal cancer using a combination of target therapy and immunotherapy.