Grants - V Scholar Grants - Maryland - 2021

Catherine Marshall, MD

FUNDED BY THE STUART SCOTT MEMORIAL CANCER RESEARCH FUND WITH SUPPORT FROM BRISTOL MYERS SQUIBB

Heart disease and low blood counts are common complications for men with prostate cancer.   There are some reasons why this might happen that are already known – either because of the cancer itself or because of some of the treatments for cancer.  Recently, scientists have found that white blood cell clones (cells that all come from one cell; called CHIP) have changes in their DNA that might put people at higher risk for heart disease, complications with blood counts, and death.  CHIP, like prostate cancer, is associated with age, and may be contributing to heart disease and blood count problems we see in men with prostate cancer.  This study will look to see if men who have CHIP with prostate cancer have worse outcomes and if new treatments for prostate cancer contribute to CHIP.