HPV is a very common virus. Most of the time, the body clears it on its own. But sometimes HPV sticks around and causes abnormal cells to grow in the cervix, anus, genitals, or throat. If those abnormal cells aren’t caught and treated, they can turn into cancer.Right now, getting treated usually means clinic visits, special tests, and sometimes painful procedures to remove the abnormal cells. For people in rural areas, Native communities, or places without good healthcare access, that’s a real barrier. People living with HIV face even higher risk because their bodies have a harder time fighting off HPV.This means people who already have the least access to care are the most likely to develop cancers that could have been prevented.Researchers are working on a treatment that people could use at home — an antiviral that someone would apply themselves, without needing a clinic visit. Combined with at-home HPV testing and follow-up through telehealth or community health workers, this approach could make it much easier for people to get treated early.For patients, that could mean fewer procedures, less time away from work, less travel, and less of the stress that comes with waiting and worrying.The bigger goal is simple: if treatment is easier to get, more people will get it — and fewer people will develop cancer.
Michelle Ozbun, PhD
Location: The University of New Mexico Cancer Research and Treatment Center - Albuquerque
Proposal: Topical Trametinib for HPV Precancer Interception: Optimizing Dose, Formulation, Schedule, PK, and Safety in Cutaneous and Mucosal Dysplasia Models