Srinivas Viswanathan, MD, PhD

There are many types of kidney cancer and most current treatments were designed for the commonest type, called “clear-cell kidney cancer.” However, these therapies work less well in other types of kidney cancer. Unfortunately, because the different kinds of kidney cancer can look similar under the microscope, many kidney cancers are misdiagnosed.

One such cancer is “translocation renal cell carcinoma” (tRCC), which makes up about 5% of all kidney cancers in adults and over half of kidney cancers in children. Early and accurate diagnosis of tRCC is important for two reasons. First, this kidney cancer has a poor prognosis and it is vital that patients are accurately informed of their diagnosis. Moreover, an early diagnosis may give a patient the opportunity to cure the cancer through surgery before it spreads. Second, an accurate diagnosis can inform which is the best treatment for a patient to receive.

Although tRCC is frequently misdiagnosed under the microscope, it is unique in terms of the genes it expresses. In this project, we will develop methods to diagnose tRCC based on its distinctive pattern of gene expression. We will apply these methods to both biopsies of tumor tissue and so-called “liquid biopsies,” in which DNA from tumor cells is extracted from a routine blood draw. This work will advance the accuracy and ease with which kidney cancer is diagnosed and may lead to new ways to diagnose tRCC earlier – when it can be caught and cured before it spreads.

Justin Milner, PhD

The immune system provides critical protection against cancer. In fact, new patient therapies designed to boost immune defenses (immunotherapies) have greatly improved cancer treatment. T-cells are a key component of the immune system that can protect against tumor growth. Notably, T-cells can be harnessed for use in cancer therapies in the form of ‘adoptive cell therapy’ (ACT). ACT is an exciting approach in which T-cells are administered to a patient to help fight cancer. Encouragingly, ACTs have successfully cured certain cancer types.

However, ACT does not work well for most cancers. In our work supported by the V Foundation, we will test new strategies to improve ACTs against pancreatic cancer, one of the most lethal cancer types. Completion of this project will yield two important outcomes: 1) Increase our understanding of how the immune system fails to control cancer, and 2) Provide important insight into enhancing the effectiveness of ACT in patients with pancreatic cancer. Immune-based therapies offer hope and promise to cancer patients were traditional treatment approaches (such as chemotherapy or surgery) have failed. This project funded by the V Scholar Program explores new opportunities to enhance cancer immunotherapies.

Sushant Kumar, PhD

Vintner Grant funded by the V Foundation Wine Celebration in honor of Leslie Rudd and Family

Cancer is one of the leading causes of death across the globe. Early cancer detection can facilitate effective treatment and fewer side effects to improve patient survival and quality of life. Therefore, there is tremendous interest in using recent technological advances in DNA sequencing, medical imaging, and machine learning methods to enable early detection efforts in cancer. Early detection efforts are likely most effective among individuals genetically predisposed to cancer. Moreover, DNA mutations during the aging process can also increase the risk of developing cancer. Therefore, we aim to use population-level sequencing data to build computational methods to assess individualized risk for developing cancer. We envision that the proposed approach will provide novel insights into the role of inherited and acquired DNA mutations toward tumor growth in high-risk individuals. These insights can be employed to facilitate early detection efforts in cancer.

Keren Hilgendorf, PhD

More than 70% of adults in the USA are obese or overweight. Obesity is a known risk factor for 13 types of cancer. This includes postmenopausal breast cancer. Breast cancer is the second most common cancer among women in the USA. It affects 1 in 8 women and leads to more than 40,000 deaths a year. Obesity is associated with a 30-50% increase in breast cancer incidence.

The expanded fat pad in obese patients surrounds breast cancer cells and supports cancer growth. However, we do not yet understand how the presence of breast cancer cells changes the surrounding fat pad, and how this, in turn, supports cancer growth. We propose that there is a reciprocal cross-talk between breast cancer cells and the cells of the surrounding fat pad, and that breast cancer cells secrete factors to generate tumor-supporting cells.

Our goal is to identify these secreted factors using functional studies and mass spectrometry approaches. We will investigate the underlying mechanism of how these factors change the fat pad. Finally, we will determine the functional importance of these changes to breast cancer cell growth. We envision that our discoveries will have a major impact on obese and overweight women at elevated risk of breast cancer. In the immediate future, our discoveries highlighting the dangerous cross-talk between breast cancer cells and the surrounding obese fat pad could lead to dietary interventions and weight-loss counseling. Long-term, we are excited by the possibility that our discoveries will lead to novel screening and therapeutic strategies.

Rogelio Hernandez-Lopez, PhD

Funded by the Stuart Scott Memorial Cancer Research Fund and the V Foundation Wine Celebration for Julie Maples, in honor of Antrese Rose Allegro

Breast cancer is one of the most diagnosed cancers in women and it is the top cause of cancer death in Black and Hispanic women. While great advances have been made in the detection and treatment of breast cancers, certain forms of breast cancer remain difficult to treat.  Some patients develop resistance to current therapies leading to relapse, metastases, and ultimately death.

We are proposing to use our own immune cells to treat difficult cases of breast cancer. Our approach is to modify T cells with synthetic receptors to specifically recognize and kill breast cancer cells without harming normal tissues and organs.

We are using the T cells ability to patrol our body and modifying them to recognize specific molecular signals, such as the amount of a protein (HER2) present on the surface of cancer cells, to execute potent killing responses. If successful, our approach will lay the foundation for clinical studies, potentially will have major impact on our ability to treat effectively and safely some of the most difficult forms of breast cancer and will provide new approaches to other challenging solid cancers. 

Priya Dedhia, MD, PhD

Adrenocortical carcinoma is a cancer of the adrenal glands that often kills the patient. Drugs to treat this cancer have failed because current research models, which use cell lines or mice, are too different from the cancer itself. Cell lines made from the cancer only have one type of cancer cell, while the original cancer has many types of cancer cells. Mice have many types of cancer cells, but the mouse cancer is too different from the human version to be helpful. To develop new treatments for this cancer, we need to make a model that includes many types of human cancer cells.

Organoids, or “mini-organs,” are a new research model that has many cell types and can be made from human tissues. They have been used to study other cancers that were previously difficult to study. We developed adrenocortical carcinoma organoids, which grew and made hormones just like the original cancer. Here, we use these organoids to study different types of cells in the cancer to determine which cells are more likely to cause worse disease. With this information, we can target weaknesses in the most dangerous cancer cells to stop the cancer from progressing, reduce treatment-related side effects, and improve survival and quality of life for patients with this terrible cancer. We also expect that our new methods can be used by scientists studying other cancers to figure out which cells are the most dangerous, so that patients with other cancers can benefit from this research.

Daniel Blanco-Melo, Ph.D.

Funded by the Stuart Scott Memorial Cancer Research Fund and the V Foundation Wine Celebration in honor of Leo Slattery, 2022 Volunteer Grant Honoree

A big part of the sequences that make our DNA come from viral infections that occurred in the past. These viral ‘fossils’ are typically not active to prevent damage to our genetic material, however in many diseases, including cancer, they are turned on. While it might be logical to think that the activation of these sequences would be a bad thing, evidence suggest that some of these viral fossils were repurposed to perform functions needed for a healthy life. In fact, some viral sequences participate in the formation of the placenta, in the way our genes are activated, and in the way our cells fight other viruses. Therefore, it is possible that the reason we see these viral fossils turned on in cancers is because they are helping the body fight the formation of tumors. Our goal is to test different ways by which the activation of these viral fossils could help prevent and fight cancer. To do this we will search for all the viral fossils present in our DNA, identify sequences that help our bodies find and destroy tumor cells, and test if one special viral fossil is able to prevent tumors by turning off its energy supply. We hope our findings can help the design of novel ways to treat cancer, taking advantage of the potential beneficial roles of these ancient viral sequences.

Arnaud Augert, Ph.D.

Small Cell Lung Cancer (SCLC) is a very aggressive form of lung cancer with few treatment options. This is due, in part, to an incomplete understanding of the ways by which this cancer develops. Recent genomic analyses have identified genes that are mutated and nonfunctional in SCLC indicating that they may play an important role. Interestingly, several of those genes encode for proteins that make up a large protein complex. The normal function of this complex is to manage how DNA is organized and packed inside the nucleus of a cell. We don’t know whether and how the inactivation of this complex promotes the development of SCLC. To address this question, we have developed new biological models in which the complex can either be inactivated or reactivated. Interestingly, we have found that blocking its normal function accelerates the development of SCLC. With the support of the V Foundation, we will assess how inactivation of the complex affects DNA organization and the expression of genes. We will also use the information we learn to find new strategies to eradicate these tumors. The proposed research will lead to a better understanding of the ways by which SCLC forms and may identify more effective treatments for patients diagnosed with SCLC.

Neha Goel, MD

Funded in partnership with Miami Dolphins Foundation

Women who live in disadvantaged neighborhoods experience shorter breast cancer survival rates. One cause may be stress from social adversity. Social adversity includes exposure to violent crime, poverty, housing instability, and more. Studies have shown that this stress can lead to gene responses that increase inflammation and depress immune response. This can result in higher rates of metastasis (the spread of cancer cells to another part of the body) and shorter breast cancer survival. Previous research from our team has found that women in disadvantaged neighborhoods show these gene responses associated with worse outcomes. This study builds on this past research with a population that is both larger and more diverse. It will validate our previous findings and help us begin to identify how neighborhood disadvantage, stress, and more aggressive genes are related. It will set the stage for future interventions that can address this negative impact and reduce disparities in breast cancer survival rates.

Wenhan Zhu, Ph.D.

Colorectal cancer is the second most deadly cancer worldwide. Both bacteria in our gut and the activity of our own cells in the intestines can contribute to the risk of colorectal cancer. However, we don’t know how these two factors work together to cause cancer. Some “bad” bacteria use toxins to cause colorectal cancer. But cancer takes over 1,000 times longer than bacteria’s lifespan to develop. So why do bacteria purposefully cause cancer? We think that “bad” bacteria remodel intestinal cell activity to produce nutrients that the bacteria can use as “food.” The rewired intestinal cell metabolism helps cancer cells grow faster. In other words, cancer development is a side effect of the “bad” bacteria trying to get food. If we can better understand this process, we can develop treatments that stop the growth of the “bad” bacteria and the tumors they cause. Using experiments in mice, we will first test whether the “food” produced by the cells in our gut helps the “bad” bacteria grow better. We will then try to block this process to reduce the growth of both the “bad” bacteria and the tumors. Lastly, we will test whether what we find in animals holds true in humans. This proposal is innovative because it uses what “bad” bacteria “eat” to help us understand how they cause cancer. We hope to use what we learn to develop better, more effective treatments for patients suffering from colorectal cancer caused by “bad” bacteria.

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