Sima Ehsani Chimeh, MD

Funded by Hooters

Breast cancer is the most common cancer in women. In about one out of three cases, the cancer spreads to other parts of the body. One type, called HER2-positive breast cancer, often grows faster and is harder to treat when it spreads. Current treatments have helped many people, but they do not always work and can cause serious side effects.Our project is creating a new way to both find and treat HER2-positive breast cancer. We are developing a medicine that can deliver tiny amounts of radiation straight to cancer cells. Depending on the type of radiation used, the medicine can either help doctors see the cancer with a scan or destroy it.It works like a “smart missile.” First, it can locate the cancer in the body with a special imaging test. Then, it can carry a different type of radiation to the tumor to kill the cancer cells, while leaving most healthy cells unharmed.We believe this approach could help doctors choose the right treatment for each patient, lower the chance that the cancer will come back, and cause fewer side effects than treatments like chemotherapy. If successful, this strategy could improve both the length and quality of life for people with HER2-positive breast cancer.

Location: University of Arizona Cancer Center - Tucson
Proposal: PET-Guided Development of HER2-Targeted Radiopharmaceuticals: From 18F-Labeled Radioligands to 212Pb Radioligand Therapy in Breast Cancer
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